In broad strokes, the Drent is a healthy breed. Certainly, some individuals may suffer from any canine malady, but that isn't representative across the breed as a common issue or health concern.

From a genetic standpoint, the Drent has only a few hereditary diseases to know about and monitor in order to keep incidences low. The Drent's eyes should be monitored for the following hereditary diseases: Progressive Retinal Atrophy (PRA), Distichiasis, Entropion and Ectropion, Persistent Pupillay Membranes (PPM), and Retinal Dysplasisa.

Other diseases or abnormalities which have been found in the Drent are: The most common, but usually non-problematic, is von Willebrand disease type-I (vWD-I). Despite a high incidence rate of carriers and affected dogs in the population. To date there have been no Drents that have shown clinical sign of the disease. This means affected dogs (dogs with two copies of the gene), do not have an abnormal bleeding response. Von Willebrand disease type-I is detectable by DNA health panels. While the disease is of interest, it is not considered to be a threat for the Drent.

Amongst breed authorities, Epilepsy is considered to be the greatest current health threat to the Drent. The type of Epilepsy has not been determined. There are a several research projects underway, no results have been produced to date. There is no genetic testing available for this in the Drent. Occurrence/manifestation is uncommon.

Other health issues that can be present: hypothyroidism, cryptorchidism, hyperuricosuria, significant reactions to poisonous insect bites/stings and the absence of certain teeth. Like many breeds, hip dysplasia and elbow dysplasia should be monitored and all breeding stock screened for. Joint dysplasia is influenced by genetics and environment, so using care during the Drents' rapid growth period is advisable.